Assay Detail
Binding
CHEMBL750866
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In vitro inhibitory concentration against dog kidney Na+,K+-ATPase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium/potassium-transporting ATPase subunit alpha-1 (CHEMBL4838) ↗| Type | SINGLE PROTEIN |
| Organism | Canis lupus familiaris |
Publication
17beta-O-Aminoalkyloximes of 5beta-androstane-3beta,14beta-diol with digitalis-like activity: synthesis, cardiotonic activity, structure-activity relationships, and molecular modeling of the Na(+),K(+)-ATPase receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.56 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2068890 | — | — | 1 | 6.60 |
| CHEMBL2068972 | — | — | 1 | 6.50 |
| CHEMBL1751 | DIGOXIN | 4.0 | 1 | 6.30 |
| CHEMBL1453 | DIGITOXIGENIN | — | 1 | 6.30 |
| CHEMBL2068902 | — | — | 1 | 5.90 |
| CHEMBL2068975 | — | — | 1 | 5.80 |
| CHEMBL2069058 | — | — | 1 | 5.20 |
| CHEMBL2068981 | — | — | 1 | 4.60 |
| CHEMBL2068977 | — | — | 1 | 4.40 |
| CHEMBL2068976 | — | — | 1 | 4.00 |
| CHEMBL2068898 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2068890 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2068972 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL1751 | DIGOXIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1453 | DIGITOXIGENIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL2068902 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL2068975 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL2069058 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL2068981 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL2068977 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL2068976 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2068898 | — | IC50 | > | 100000.0 | nM | - |