Assay Detail
Binding
CHEMBL751016
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Inhibitory activity against Opioid receptor kappa 1 in electrically stimulated mouse vas deferens (MVD) preparation.
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Arylacetamide-derived fluorescent probes: synthesis, biological evaluation, and direct fluorescent labeling of kappa opioid receptors in mouse microglial cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.16 | 9.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413530 | — | — | 1 | 9.92 |
| CHEMBL1907788 | — | — | 1 | 8.92 |
| CHEMBL1907786 | — | — | 1 | 8.92 |
| CHEMBL1907789 | — | — | 1 | 8.82 |
| CHEMBL38576 | ICI-199,441 | — | 1 | 8.60 |
| CHEMBL48344 | — | — | 1 | 8.35 |
| CHEMBL1907787 | — | — | 1 | 8.19 |
| CHEMBL430971 | — | — | 1 | 7.90 |
| CHEMBL49591 | — | — | 1 | 6.99 |
| CHEMBL47318 | — | — | 1 | 6.77 |
| CHEMBL412689 | — | — | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413530 | — | IC50 | = | 0.12 | nM | 9.92 |
| CHEMBL1907788 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1907786 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL1907789 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL38576 | ICI-199,441 | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL48344 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL1907787 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL430971 | — | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL49591 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL47318 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL412689 | — | IC50 | = | 421.0 | nM | 6.38 |