Assay Detail
Binding
CHEMBL751022
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Inhibition of neutral endopeptidase (NEP) 24.11
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
-Mercaptoacyl dipeptides that inhibit angiotensin converting enzyme and neutral endopeptidase 24.11
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.79 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL358338 | — | — | 1 | 7.55 |
| CHEMBL163182 | — | — | 1 | 7.48 |
| CHEMBL161879 | — | — | 1 | 7.37 |
| CHEMBL351878 | — | — | 1 | 7.23 |
| CHEMBL163454 | — | — | 1 | 7.00 |
| CHEMBL165888 | — | — | 1 | 6.93 |
| CHEMBL163468 | — | — | 1 | 6.65 |
| CHEMBL349594 | — | — | 1 | 6.42 |
| CHEMBL163621 | — | — | 1 | 6.30 |
| CHEMBL166083 | — | — | 1 | 6.23 |
| CHEMBL350414 | — | — | 1 | 6.18 |
| CHEMBL423635 | — | — | 1 | 6.15 |
| CHEMBL350378 | — | — | 1 | - |
| CHEMBL351318 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL358338 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL163182 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL161879 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL351878 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL163454 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL165888 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL163468 | — | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL349594 | — | IC50 | = | 385.0 | nM | 6.42 |
| CHEMBL163621 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL166083 | — | IC50 | = | 583.0 | nM | 6.23 |
| CHEMBL350414 | — | IC50 | = | 654.0 | nM | 6.18 |
| CHEMBL423635 | — | IC50 | = | 705.0 | nM | 6.15 |
| CHEMBL350378 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL351318 | — | IC50 | > | 1000.0 | nM | - |