Assay Detail
Binding
CHEMBL751029
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Inhibitory activity against neutral endopeptidase (NEP)prepared from microsomal fractions of rat small intestine
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Aminophosphonate endothelin converting enzyme inhibitors: potency-enhancing and selectivity-improving modifications of phosphoramidon
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.89 | 8.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL479579 | PHOSPHORAMIDON | — | 1 | 8.38 |
| CHEMBL281333 | — | — | 1 | 7.62 |
| CHEMBL282663 | — | — | 1 | 6.89 |
| CHEMBL277199 | — | — | 1 | 6.89 |
| CHEMBL25269 | — | — | 1 | 6.85 |
| CHEMBL279255 | — | — | 1 | 6.26 |
| CHEMBL283758 | — | — | 1 | 6.25 |
| CHEMBL277195 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL479579 | PHOSPHORAMIDON | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL281333 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL282663 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL277199 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL25269 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL279255 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL283758 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL277195 | — | IC50 | = | 1100.0 | nM | 5.96 |