Assay Detail
Binding
CHEMBL751038
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Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
High-affinity, non-peptide agonists for the ORL1 (orphanin FQ/nociceptin) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.90 | 8.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284414 | — | — | 1 | 8.28 |
| CHEMBL28198 | — | — | 1 | 8.26 |
| CHEMBL27460 | — | — | 1 | 7.97 |
| CHEMBL26638 | — | — | 1 | 7.77 |
| CHEMBL283432 | — | — | 1 | 7.76 |
| CHEMBL27716 | — | — | 1 | 7.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284414 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL28198 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL27460 | — | Ki | = | 10.7 | nM | 7.97 |
| CHEMBL26638 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL283432 | — | Ki | = | 17.5 | nM | 7.76 |
| CHEMBL27716 | — | Ki | = | 46.3 | nM | 7.33 |