Compound Detail
CHEMBL26638
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Basic Information
| ChEMBL ID | CHEMBL26638 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NKJVDKFKDYMREK-NRFANRHFSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
361.5
MW (Da)
3.49
ALogP
3
HBA
1
HBD
35.6
PSA (Ų)
0.89
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 7.99
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nociceptin receptor CHEMBL2014 | Ki | 7.99 | 7.99 | 10.2 | 1 |
| Mu-type opioid receptor CHEMBL233 | Ki | 7.88 | 7.88 | 13.3 | 1 |
| Kappa-type opioid receptor CHEMBL237 | Ki | 7.77 | 7.77 | 17.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nociceptin receptor | Ki | = | 10.2 | nM | 7.99 | Competitive binding affinity against transfected HEK293 cells expressing Opioid ... | 10753470 |
| Mu-type opioid receptor | Ki | = | 13.3 | nM | 7.88 | Competitive binding displacement analyses was performed from permanently transfe... | 10753470 |
| Kappa-type opioid receptor | Ki | = | 17.0 | nM | 7.77 | Competitive binding displacement analyses was performed from permanently transfe... | 10753470 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10753470 | 10.1021/jm991129q | Nociceptin receptor | 1 |
| 10753470 | 10.1021/jm991129q | Mu-type opioid receptor | 1 |
| 10753470 | 10.1021/jm991129q | Kappa-type opioid receptor | 1 |
Data from ChEMBL 36 via Core Engine