Assay Detail
Binding
CHEMBL751053
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Concentration required for inhibition of [3H]DAMGO binding to Opioid receptor mu 1 in rat brain membranes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and binding activity of endomorphin-1 analogues containing beta-amino acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.27 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313820 | — | — | 1 | 8.74 |
| CHEMBL38874 | DAMGO | — | 1 | 8.01 |
| CHEMBL316446 | ENDOMORPHIN-1 | — | 1 | 7.25 |
| CHEMBL316447 | — | — | 1 | 7.14 |
| CHEMBL329996 | — | — | 1 | 6.33 |
| CHEMBL92693 | — | — | 1 | 6.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313820 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL38874 | DAMGO | IC50 | = | 9.89 | nM | 8.01 |
| CHEMBL316446 | ENDOMORPHIN-1 | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL316447 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL329996 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL92693 | — | IC50 | = | 680.0 | nM | 6.17 |