Assay Detail
Binding
CHEMBL751064
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Inhibition of binding of radioligand [3H]CTOP to Opioid receptor mu 1 in rat brain
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Cyclic enkephalin analogues with exceptional potency and selectivity for delta-opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.57 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339320 | — | — | 1 | 6.55 |
| CHEMBL129252 | — | — | 1 | 5.78 |
| CHEMBL340537 | — | — | 1 | 5.77 |
| CHEMBL31421 | — | — | 1 | 5.43 |
| CHEMBL340176 | — | — | 1 | 5.38 |
| CHEMBL341535 | — | — | 1 | 5.14 |
| CHEMBL338462 | — | — | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339320 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL129252 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL340537 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL31421 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL340176 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL341535 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL338462 | — | IC50 | = | 11400.0 | nM | 4.94 |