Assay Detail
Binding
CHEMBL751070
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Inhibitory concentration against [3H]DAMGO binding to Opioid receptor mu 1 in rat brain membrane
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Beta-casomorphins: substitution of phenylalanine with beta-homo phenylalanine increases the mu-type opioid receptor affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.29 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3142988 | — | — | 1 | 5.70 |
| CHEMBL2370579 | — | — | 1 | 5.40 |
| CHEMBL2370515 | — | — | 1 | 5.35 |
| CHEMBL2370605 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3142988 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2370579 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2370515 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL2370605 | — | IC50 | = | 20000.0 | nM | 4.70 |