Assay Detail
Binding
CHEMBL751135
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Tested for the ability to inhibit the specific binding of [3H]-CGS- 19755 to NMDA recognition sites on rat brain membranes
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Pharmacology of (2R, 4R, 5S)-2-amino-4,5-(1,2-cyclohexyl)-7-phosphonoheptanoic acid (NPC 17742); a selective, systemically active, competitive NMDA antagonist
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.84 | 7.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39664 | SELFOTEL | 2.0 | 1 | 7.06 |
| CHEMBL22304 | — | — | 1 | 6.72 |
| CHEMBL107660 | — | — | 1 | 6.57 |
| CHEMBL107961 | — | — | 1 | 5.62 |
| CHEMBL108823 | — | — | 1 | 5.58 |
| CHEMBL340085 | — | — | 2 | 5.39 |
| CHEMBL108096 | — | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39664 | SELFOTEL | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL22304 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL107660 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL107961 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL108823 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL340085 | — | IC50 | = | 4050.0 | nM | 5.39 |
| CHEMBL108096 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL340085 | — | IC50 | = | 28000.0 | nM | 4.55 |