Assay Detail
Binding
CHEMBL751162
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]mazindol binding to Norepinephrine transporter
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Isopropyl and phenyl esters of 3 beta-(4-substituted phenyl)tropan-2 beta-carboxylic acids. Potent and selective compounds for the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.66 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311347 | — | — | 1 | 7.46 |
| CHEMBL312037 | — | — | 1 | 7.36 |
| CHEMBL610897 | — | — | 1 | 7.35 |
| CHEMBL82946 | — | — | 1 | 6.06 |
| CHEMBL2079586 | — | — | 1 | 5.91 |
| CHEMBL83729 | — | — | 1 | 5.68 |
| CHEMBL82093 | — | — | 1 | 5.67 |
| CHEMBL370805 | COCAINE | 4.0 | 1 | 5.42 |
| CHEMBL309635 | — | — | 1 | 5.37 |
| CHEMBL310573 | — | — | 1 | 5.34 |
| CHEMBL86165 | — | — | 1 | 4.96 |
| CHEMBL313038 | — | — | 1 | 4.74 |
| CHEMBL314465 | — | — | 1 | 4.63 |
| CHEMBL310131 | — | — | 1 | 4.57 |
| CHEMBL314464 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311347 | — | IC50 | = | 34.6 | nM | 7.46 |
| CHEMBL312037 | — | IC50 | = | 43.6 | nM | 7.36 |
| CHEMBL610897 | — | IC50 | = | 45.1 | nM | 7.35 |
| CHEMBL82946 | — | IC50 | = | 864.0 | nM | 6.06 |
| CHEMBL2079586 | — | IC50 | = | 1237.0 | nM | 5.91 |
| CHEMBL83729 | — | IC50 | = | 2085.0 | nM | 5.68 |
| CHEMBL82093 | — | IC50 | = | 2154.0 | nM | 5.67 |
| CHEMBL370805 | COCAINE | IC50 | = | 3825.0 | nM | 5.42 |
| CHEMBL309635 | — | IC50 | = | 4295.0 | nM | 5.37 |
| CHEMBL310573 | — | IC50 | = | 4574.0 | nM | 5.34 |
| CHEMBL86165 | — | IC50 | = | 10845.0 | nM | 4.96 |
| CHEMBL313038 | — | IC50 | = | 18277.0 | nM | 4.74 |
| CHEMBL314465 | — | IC50 | = | 23547.0 | nM | 4.63 |
| CHEMBL310131 | — | IC50 | = | 26808.0 | nM | 4.57 |
| CHEMBL314464 | — | IC50 | = | 37435.0 | nM | 4.43 |