Assay Detail
Binding
CHEMBL751182
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity evaluated by its ability to displace [3H]CPP from rat cortical membrane receptor at 10E-5 concentration of the compound
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Exploration of N-phosphonoalkyl-, N-phosphonoalkenyl-, and N-(phosphonoalkyl)phenyl-spaced alpha-amino acids as competitive N-methyl-D-aspartic acid antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.31 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29244 | — | — | 1 | 7.19 |
| CHEMBL22304 | — | — | 1 | 7.10 |
| CHEMBL29255 | — | — | 1 | 6.00 |
| CHEMBL27735 | — | — | 1 | 5.64 |
| CHEMBL28609 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29244 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL22304 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL29255 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL27735 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL28609 | — | IC50 | = | 2400.0 | nM | 5.62 |