Assay Detail
Binding
CHEMBL751183
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against radioligand [3H]CGS-19,755 binding to N-methyl-D-aspartate glutamate receptor in rat forebrain membranes
5
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Forebrain |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Design, synthesis, and pharmacological characterization of (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740): a potent, selective, and orally active group 2 metabotropic glutamate receptor agonist possessing anticonvulsant and anxiolytic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.21 | 4.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL358200 | — | — | 1 | 4.21 |
| CHEMBL8759 | EGLUMETAD | 2.0 | 3 | - |
| CHEMBL280563 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL358200 | — | IC50 | = | 62400.0 | nM | 4.21 |
| CHEMBL8759 | EGLUMETAD | IC50 | > | 100000.0 | nM | - |
| CHEMBL8759 | EGLUMETAD | IC50 | > | 100000.0 | nM | - |
| CHEMBL280563 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL8759 | EGLUMETAD | IC50 | > | 100000.0 | nM | - |