Assay Detail
Functional
CHEMBL751232
Review assay metadata, readout intent, target linkage, and publication context from the same page.
NMDA receptor antagonistic activity was assessed from the ability to displace [3H]CPP29,30 from rat cortical membranes.
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Exploration of phenyl-spaced 2-amino-(5-9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.30 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274440 | AP-7 | — | 1 | 6.10 |
| CHEMBL30021 | — | — | 1 | 5.03 |
| CHEMBL29184 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274440 | AP-7 | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL30021 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL29184 | — | IC50 | = | 17450.0 | nM | 4.76 |