Assay Detail
Binding
CHEMBL751238
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]MK-801 from rat brain membrane N-methyl-D-aspartate glutamate receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.26 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL112806 | — | — | 1 | 5.66 |
| CHEMBL28853 | — | — | 1 | 5.60 |
| CHEMBL109210 | — | — | 1 | 5.48 |
| CHEMBL326502 | — | — | 1 | 5.46 |
| CHEMBL112132 | — | — | 1 | 5.40 |
| CHEMBL326741 | — | — | 1 | 5.11 |
| CHEMBL78083 | — | — | 1 | 5.10 |
| CHEMBL110909 | — | — | 1 | 5.00 |
| CHEMBL81602 | — | — | 1 | 4.99 |
| CHEMBL81626 | — | — | 1 | 4.75 |
| CHEMBL320340 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL112806 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL28853 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL109210 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL326502 | — | IC50 | = | 3480.0 | nM | 5.46 |
| CHEMBL112132 | — | IC50 | = | 4010.0 | nM | 5.40 |
| CHEMBL326741 | — | IC50 | = | 7790.0 | nM | 5.11 |
| CHEMBL78083 | — | IC50 | = | 7910.0 | nM | 5.10 |
| CHEMBL110909 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL81602 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL81626 | — | IC50 | = | 17900.0 | nM | 4.75 |
| CHEMBL320340 | — | IC50 | > | 7700.0 | nM | - |