Assay Detail
Binding
CHEMBL751242
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for its affinity against N-methyl-D-aspartate glutamate receptor in rats using [3H]CPP as radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Bioisosteric replacement of the alpha-amino carboxylic acid functionality in 2-amino-5-phosphonopentanoic acid yields unique 3,4-diamino-3-cyclobutene-1,2-dione containing NMDA antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.97 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83688 | — | — | 1 | 6.33 |
| CHEMBL143852 | — | — | 1 | 6.00 |
| CHEMBL145806 | — | — | 1 | 5.58 |
| CHEMBL142917 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83688 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL143852 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL145806 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL142917 | — | IC50 | > | 10000.0 | nM | - |