Assay Detail
Binding
CHEMBL751277
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Binding affinity towards nicotinic acetylcholine receptor (nAChR) using [3H]cytisine as radioligand in rat brain
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Neuronal acetylcholine receptor (CHEMBL2094110) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis and analgesic activity of hydrochlorides and quaternary ammoniums of epibatidine incorporated with amino acid ester.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 6.60 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL47814 | DIMETHYLPHENYLPIPERAZINIUM IODIDE | — | 1 | 6.60 |
| CHEMBL137134 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL47814 | DIMETHYLPHENYLPIPERAZINIUM IODIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL137134 | — | Ki | > | 10000.0 | nM | - |