Assay Detail
Functional
CHEMBL751305
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Na+ influx in chinese hamster ovary cells expressing rat brain sodium channel type IIA
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | ovary |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium channel protein type 2 subunit alpha (CHEMBL3399) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacological evaluation of phenylacetamides as sodium-channel blockers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.85 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507974 | TETRODOTOXIN | 3.0 | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507974 | TETRODOTOXIN | IC50 | = | 14.0 | nM | 7.85 |