Assay Detail
Functional
CHEMBL751310
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Inhibition of NIH 3T3 cell growth required to induce 50% of maximum response using antiproliferative assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, pharmacokinetics, efficacy, and rat retinal toxicity of a novel mitomycin C-triamcinolone acetonide conjugate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.70 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13829 | MIXTURE OF MMC AND TA | — | 1 | 5.80 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.77 |
| CHEMBL14411 | — | — | 1 | 5.62 |
| CHEMBL1504 | TRIAMCINOLONE ACETONIDE | 4.0 | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13829 | MIXTURE OF MMC AND TA | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL14411 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1504 | TRIAMCINOLONE ACETONIDE | IC50 | = | 2500.0 | nM | 5.60 |