Assay Detail
Functional
CHEMBL751316
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Inhibition of serum stimulated NIH3T3 cell proliferation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis of a prodrug designed to release multiple inhibitors of the epidermal growth factor receptor tyrosine kinase and an alkylating agent: a novel tumor targeting concept.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.70 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL152448 | — | — | 1 | 4.89 |
| CHEMBL52765 | — | — | 1 | 4.84 |
| CHEMBL152922 | — | — | 1 | 4.81 |
| CHEMBL7917 | TYRPHOSTIN AG-1478 | — | 1 | 4.54 |
| CHEMBL152739 | — | — | 1 | 4.41 |
| CHEMBL137617 | — | — | 1 | - |
| CHEMBL153577 | — | — | 1 | - |
| CHEMBL356435 | — | — | 1 | - |
| CHEMBL137189 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL152448 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL52765 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL152922 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL7917 | TYRPHOSTIN AG-1478 | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL152739 | — | IC50 | = | 39400.0 | nM | 4.41 |
| CHEMBL137617 | — | IC50 | = | 150500.0 | nM | - |
| CHEMBL153577 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL356435 | — | IC50 | = | 214000.0 | nM | - |
| CHEMBL137189 | — | IC50 | = | 125000.0 | nM | - |