Assay Detail
Functional
CHEMBL751319
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Effective concentration against Ha-RAS processing in NIH3T3 ras-transformed cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Novel and selective imidazole-containing biphenyl inhibitors of protein farnesyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.41 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 8.70 |
| CHEMBL27843 | — | — | 1 | 7.30 |
| CHEMBL28707 | — | — | 1 | 7.16 |
| CHEMBL282959 | — | — | 1 | 7.10 |
| CHEMBL298734 | LONAFARNIB | 4.0 | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289228 | TIPIFARNIB | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL27843 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL28707 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL282959 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL298734 | LONAFARNIB | EC50 | = | 160.0 | nM | 6.80 |