Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL751415

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human non-small-cell lung carcinoma cell line H460 (NSCLC-H460)
ChEMBL ↗
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type carcinoma cell line
Confidence 1 — Organism
Curated By Autocuration

Target

NON-PROTEIN TARGET (CHEMBL3879801) ↗
Type NON-MOLECULAR

Publication

Novel 7-oxyiminomethyl derivatives of camptothecin with potent in vitro and in vivo antitumor activity.
Dallavalle S, Ferrari A, Biasotti B, Merlini L, Penco S, Gallo G, Marzi M, Tinti MO, Martinelli R, Pisano C, Carminati P, Carenini N, Beretta G, Perego P, De Cesare M, Pratesi G, Zunino F.
J Med Chem (2001) 44 : 3264 -3274
PubMed 11563925 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 39 6.62 7.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL113051 GIMATECAN 2.0 1 7.82
CHEMBL424435 — — 1 7.77
CHEMBL323422 — — 1 7.70
CHEMBL324202 — — 1 7.70
CHEMBL112308 — — 1 7.60
CHEMBL322811 — — 1 7.55
CHEMBL111767 — — 1 7.52
CHEMBL326907 — — 1 7.52
CHEMBL326720 — — 1 7.50
CHEMBL111012 — — 1 7.40
CHEMBL112962 — — 1 7.22
CHEMBL109359 — — 1 7.16
CHEMBL325393 — — 1 7.16
CHEMBL325254 — — 1 7.10
CHEMBL837 7-ETHYL-10-HYDROXYCAMPTOTHECIN 2.0 1 7.10
CHEMBL323751 — — 1 7.00
CHEMBL112769 — — 1 6.89
CHEMBL322337 — — 1 6.89
CHEMBL111209 — — 1 6.85
CHEMBL113482 — — 1 6.80
CHEMBL320127 — — 1 6.70
CHEMBL112334 — — 1 6.68
CHEMBL113558 — — 1 6.55
CHEMBL113393 — — 1 6.52
CHEMBL65 CAMPTOTHECIN -1.0 1 6.48
CHEMBL114135 — — 1 6.47
CHEMBL3215370 — — 1 6.44
CHEMBL419186 — — 1 6.31
CHEMBL322141 — — 1 6.30
CHEMBL84 TOPOTECAN 4.0 1 5.86

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL113051 GIMATECAN IC50 = 15.0 nM 7.82
CHEMBL424435 — IC50 = 17.0 nM 7.77
CHEMBL324202 — IC50 = 20.0 nM 7.70
CHEMBL323422 — IC50 = 20.0 nM 7.70
CHEMBL112308 — IC50 = 25.0 nM 7.60
CHEMBL322811 — IC50 = 28.0 nM 7.55
CHEMBL111767 — IC50 = 30.0 nM 7.52
CHEMBL326907 — IC50 = 30.0 nM 7.52
CHEMBL326720 — IC50 = 32.0 nM 7.50
CHEMBL111012 — IC50 = 40.0 nM 7.40
CHEMBL112962 — IC50 = 60.0 nM 7.22
CHEMBL109359 — IC50 = 70.0 nM 7.16
CHEMBL325393 — IC50 = 70.0 nM 7.16
CHEMBL325254 — IC50 = 80.0 nM 7.10
CHEMBL837 7-ETHYL-10-HYDROXYCAMPTOTHECIN IC50 = 80.0 nM 7.10
CHEMBL323751 — IC50 = 100.0 nM 7.00
CHEMBL112769 — IC50 = 130.0 nM 6.89
CHEMBL322337 — IC50 = 130.0 nM 6.89
CHEMBL111209 — IC50 = 140.0 nM 6.85
CHEMBL113482 — IC50 = 160.0 nM 6.80
CHEMBL320127 — IC50 = 200.0 nM 6.70
CHEMBL112334 — IC50 = 210.0 nM 6.68
CHEMBL113558 — IC50 = 280.0 nM 6.55
CHEMBL113393 — IC50 = 300.0 nM 6.52
CHEMBL65 CAMPTOTHECIN IC50 = 330.0 nM 6.48
CHEMBL114135 — IC50 = 340.0 nM 6.47
CHEMBL3215370 — IC50 = 360.0 nM 6.44
CHEMBL419186 — IC50 = 490.0 nM 6.31
CHEMBL322141 — IC50 = 500.0 nM 6.30
CHEMBL84 TOPOTECAN IC50 = 1380.0 nM 5.86
CHEMBL321273 — IC50 = 1700.0 nM 5.77
CHEMBL109556 — IC50 = 1770.0 nM 5.75
CHEMBL109233 — IC50 = 2330.0 nM 5.63
CHEMBL419035 — IC50 = 2400.0 nM 5.62
CHEMBL109734 — IC50 = 3000.0 nM 5.52
CHEMBL112757 — IC50 = 5130.0 nM 5.29
CHEMBL322063 — IC50 = 5200.0 nM 5.28
CHEMBL444535 — IC50 = 32000.0 nM 4.50
CHEMBL324292 — IC50 = 48000.0 nM 4.32