Assay Detail
Binding
CHEMBL751448
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [3H]- nisoxetin from Norepinephrine transporter in rat cerebral cortical homogenate
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of a series of novel N- or O-fluoroalkyl derivatives of tropane: potential positron emission tomography (PET) imaging agents for the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.99 | 8.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL14613 | — | — | 1 | 8.73 |
| CHEMBL311347 | — | — | 1 | 8.55 |
| CHEMBL318755 | — | — | 1 | 7.20 |
| CHEMBL318961 | — | — | 1 | 6.76 |
| CHEMBL105693 | — | — | 1 | 6.76 |
| CHEMBL433159 | — | — | 1 | 6.71 |
| CHEMBL430504 | — | — | 1 | 6.58 |
| CHEMBL105089 | — | — | 1 | 6.57 |
| CHEMBL317444 | — | — | 1 | 6.14 |
| CHEMBL319052 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL14613 | — | Ki | = | 1.85 | nM | 8.73 |
| CHEMBL311347 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL318755 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL318961 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL105693 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL433159 | — | Ki | = | 196.0 | nM | 6.71 |
| CHEMBL430504 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL105089 | — | Ki | = | 268.0 | nM | 6.57 |
| CHEMBL317444 | — | Ki | = | 723.0 | nM | 6.14 |
| CHEMBL319052 | — | Ki | = | 1208.0 | nM | 5.92 |