Assay Detail
Binding
CHEMBL751450
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Displacement of [3H]-nisoxatine from Norepinephrine transporter of rat forebrain membrane
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis of 3 beta-aryl-8-azabicyclo[3.2.1]octanes with high binding affinities and selectivities for the serotonin transporter site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.88 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418190 | — | — | 1 | 8.54 |
| CHEMBL87983 | — | — | 1 | 8.26 |
| CHEMBL85492 | — | — | 1 | 7.96 |
| CHEMBL314361 | — | — | 1 | 7.11 |
| CHEMBL85877 | — | — | 1 | 7.03 |
| CHEMBL85256 | — | — | 1 | 6.82 |
| CHEMBL23142 | — | — | 1 | 6.80 |
| CHEMBL36720 | — | — | 1 | 6.36 |
| CHEMBL82807 | — | — | 1 | 6.10 |
| CHEMBL84899 | — | — | 1 | 5.37 |
| CHEMBL87678 | — | — | 1 | 5.29 |
| CHEMBL278122 | — | — | 1 | - |
| CHEMBL314919 | — | — | 1 | - |
| CHEMBL87739 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418190 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL87983 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL85492 | — | Ki | = | 10.9 | nM | 7.96 |
| CHEMBL314361 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL85877 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL85256 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL23142 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL36720 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL82807 | — | Ki | = | 794.0 | nM | 6.10 |
| CHEMBL84899 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL87678 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL278122 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL314919 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL87739 | — | Ki | > | 10000.0 | nM | - |