Assay Detail
Binding
CHEMBL751455
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Compound was evaluated for in vitro inhibition of [3H]MK-801 at NMDA receptor
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.26 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1744058 | — | — | 1 | 6.48 |
| CHEMBL553701 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1744058 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL553701 | — | EC50 | = | 930.0 | nM | 6.03 |