Assay Detail
Binding
CHEMBL751465
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding potency for NMDA site of the glutamate receptor complex using rat brain cortical membranes in a competitive binding assay with [3H]CPP as the radioligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Competitive NMDA receptor antagonists: synthesis of -ketophosphonate-substituted piperidine carboxylic acid derivatives
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.67 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305487 | — | — | 1 | 8.49 |
| CHEMBL67689 | — | — | 1 | 8.12 |
| CHEMBL308011 | — | — | 1 | 7.82 |
| CHEMBL281190 | — | — | 1 | 7.40 |
| CHEMBL303393 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305487 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL67689 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL308011 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL281190 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL303393 | — | IC50 | = | 320.0 | nM | 6.50 |