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Assay Detail

CHEMBL751483

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Selective inhibition of serum stimulated growth of NIH3T3neu isogenic cells
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type NIH3T3
Confidence 1 — Organism
Curated By Expert

Target

NIH3T3 (CHEMBL614822)
Type CELL-LINE
Organism Mus musculus

Publication

The combi-targeting concept: chemical dissection of the dual targeting properties of a series of "combi-triazenes".
Rachid Z, Brahimi F, Katsoulas A, Teoh N, Jean-Claude BJ.
J Med Chem (2003) 46 : 4313 -4321
PubMed 13678409 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 4.99 5.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL137364 1 5.54
CHEMBL136674 1 5.53
CHEMBL136491 1 5.51
CHEMBL137534 1 5.47
CHEMBL134312 1 5.43
CHEMBL138125 1 5.39
CHEMBL52765 1 5.39
CHEMBL133024 1 5.38
CHEMBL137617 1 5.37
CHEMBL343352 1 5.31
CHEMBL133023 1 5.16
CHEMBL336113 1 5.14
CHEMBL137189 1 5.01
CHEMBL424093 1 4.95
CHEMBL344652 1 4.50
CHEMBL332096 1 4.47
CHEMBL137027 1 4.47
CHEMBL137788 1 4.46
CHEMBL137635 1 4.19
CHEMBL135592 1 4.09
CHEMBL136492 1 4.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL137364 IC50 = 2920.0 nM 5.54
CHEMBL136674 IC50 = 2980.0 nM 5.53
CHEMBL136491 IC50 = 3090.0 nM 5.51
CHEMBL137534 IC50 = 3400.0 nM 5.47
CHEMBL134312 IC50 = 3740.0 nM 5.43
CHEMBL138125 IC50 = 4060.0 nM 5.39
CHEMBL52765 IC50 = 4100.0 nM 5.39
CHEMBL133024 IC50 = 4160.0 nM 5.38
CHEMBL137617 IC50 = 4320.0 nM 5.37
CHEMBL343352 IC50 = 4930.0 nM 5.31
CHEMBL133023 IC50 = 6940.0 nM 5.16
CHEMBL336113 IC50 = 7200.0 nM 5.14
CHEMBL137189 IC50 = 9690.0 nM 5.01
CHEMBL424093 IC50 = 11230.0 nM 4.95
CHEMBL344652 IC50 = 31640.0 nM 4.50
CHEMBL332096 IC50 = 33790.0 nM 4.47
CHEMBL137027 IC50 = 33900.0 nM 4.47
CHEMBL137788 IC50 = 34910.0 nM 4.46
CHEMBL137635 IC50 = 64090.0 nM 4.19
CHEMBL135592 IC50 = 81050.0 nM 4.09
CHEMBL136492 IC50 = 99370.0 nM 4.00