Assay Detail
Binding
CHEMBL751553
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Binding activity to muscarinic acetylcholine receptor in rat heart, assayed using [3H]-QNB as a radioligand.
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Chemical and biochemical studies of 2-propynylpyrrolidine derivatives. Restricted-rotation analogues of N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide (BM-5).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 5.55 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | — | 1 | 8.40 |
| CHEMBL310852 | — | — | 1 | 7.16 |
| CHEMBL108439 | — | — | 1 | 6.89 |
| CHEMBL2092936 | — | — | 1 | 6.21 |
| CHEMBL107491 | — | — | 1 | 6.07 |
| CHEMBL2111700 | — | — | 1 | 6.03 |
| CHEMBL2092935 | — | — | 1 | 5.91 |
| CHEMBL326905 | — | — | 1 | 5.88 |
| CHEMBL1203014 | — | — | 1 | 5.81 |
| CHEMBL2111697 | — | — | 1 | 5.68 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 5.63 |
| CHEMBL2111696 | — | — | 1 | 5.53 |
| CHEMBL2111699 | — | — | 1 | 5.49 |
| CHEMBL111087 | — | — | 1 | 5.36 |
| CHEMBL2111695 | — | — | 1 | 5.29 |
| CHEMBL2092934 | — | — | 1 | 5.23 |
| CHEMBL1203010 | — | — | 1 | 5.19 |
| CHEMBL110208 | — | — | 1 | 5.12 |
| CHEMBL1203012 | — | — | 1 | 5.04 |
| CHEMBL2111698 | — | — | 1 | 4.93 |
| CHEMBL2092938 | — | — | 1 | 4.89 |
| CHEMBL107713 | — | — | 1 | 4.87 |
| CHEMBL1203011 | — | — | 1 | 4.81 |
| CHEMBL321684 | — | — | 1 | 4.79 |
| CHEMBL1203013 | — | — | 1 | 4.70 |
| CHEMBL2092937 | — | — | 1 | 4.54 |
| CHEMBL108411 | — | — | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL310852 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL108439 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL2092936 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL107491 | — | Ki | = | 850.0 | nM | 6.07 |
| CHEMBL2111700 | — | Ki | = | 940.0 | nM | 6.03 |
| CHEMBL2092935 | — | Ki | = | 1230.0 | nM | 5.91 |
| CHEMBL326905 | — | Ki | = | 1320.0 | nM | 5.88 |
| CHEMBL1203014 | — | Ki | = | 1550.0 | nM | 5.81 |
| CHEMBL2111697 | — | Ki | = | 2070.0 | nM | 5.68 |
| CHEMBL14 | CARBACHOL | Ki | = | 2340.0 | nM | 5.63 |
| CHEMBL2111696 | — | Ki | = | 2940.0 | nM | 5.53 |
| CHEMBL2111699 | — | Ki | = | 3260.0 | nM | 5.49 |
| CHEMBL111087 | — | Ki | = | 4420.0 | nM | 5.36 |
| CHEMBL2111695 | — | Ki | = | 5160.0 | nM | 5.29 |
| CHEMBL2092934 | — | Ki | = | 5910.0 | nM | 5.23 |
| CHEMBL1203010 | — | Ki | = | 6400.0 | nM | 5.19 |
| CHEMBL110208 | — | Ki | = | 7620.0 | nM | 5.12 |
| CHEMBL1203012 | — | Ki | = | 9190.0 | nM | 5.04 |
| CHEMBL2111698 | — | Ki | = | 11800.0 | nM | 4.93 |
| CHEMBL2092938 | — | Ki | = | 12900.0 | nM | 4.89 |
| CHEMBL107713 | — | Ki | = | 13400.0 | nM | 4.87 |
| CHEMBL1203011 | — | Ki | = | 15500.0 | nM | 4.81 |
| CHEMBL321684 | — | Ki | = | 16400.0 | nM | 4.79 |
| CHEMBL1203013 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL2092937 | — | Ki | = | 28500.0 | nM | 4.54 |
| CHEMBL108411 | — | Ki | = | 51700.0 | nM | 4.29 |