Assay Detail
Binding
CHEMBL751564
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Inhibition of [3H]-CGS- 19755 binding to N-methyl-D-aspartate glutamate receptor in rat crude synaptic membranes
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
4-(Phosphonoalkyl)- and 4-(phosphonoalkenyl)-2-piperidinecarboxylic acids: synthesis, activity at N-methyl-D-aspartic acid receptors, and anticonvulsant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.51 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL26475 | — | — | 1 | 7.85 |
| CHEMBL283032 | — | — | 1 | 7.41 |
| CHEMBL29692 | — | — | 1 | 7.14 |
| CHEMBL284445 | — | — | 1 | 7.11 |
| CHEMBL28523 | — | — | 1 | 7.10 |
| CHEMBL68966 | — | — | 1 | 6.98 |
| CHEMBL30161 | — | — | 1 | 6.34 |
| CHEMBL281485 | — | — | 1 | 6.10 |
| CHEMBL29465 | — | — | 1 | 5.89 |
| CHEMBL30127 | — | — | 1 | 5.89 |
| CHEMBL282162 | — | — | 1 | 5.80 |
| CHEMBL69691 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL26475 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL283032 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL29692 | — | IC50 | = | 72.0 | nM | 7.14 |
| CHEMBL284445 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL28523 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL68966 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL30161 | — | IC50 | = | 452.0 | nM | 6.34 |
| CHEMBL281485 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL29465 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL30127 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL282162 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL69691 | — | IC50 | = | 28000.0 | nM | 4.55 |