Assay Detail
Binding
CHEMBL751565
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]-CGS- 19755 binding to N-methyl-D-aspartic acid receptors in rat crude synaptic membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
4-(Phosphonoalkyl)- and 4-(phosphonoalkenyl)-2-piperidinecarboxylic acids: synthesis, activity at N-methyl-D-aspartic acid receptors, and anticonvulsant activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.73 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39664 | SELFOTEL | 2.0 | 1 | 7.50 |
| CHEMBL68517 | — | — | 1 | 7.01 |
| CHEMBL22304 | — | — | 1 | 6.66 |
| CHEMBL71898 | — | — | 1 | 6.46 |
| CHEMBL302783 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39664 | SELFOTEL | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL68517 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL22304 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL71898 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL302783 | — | IC50 | = | 912.0 | nM | 6.04 |