Assay Detail
Binding
CHEMBL751606
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against P-glycoprotein expressed in murine mammary carcinoma (EMT6/AR1.0 cell line) in single-dose potentiation assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of new templates derived from pyrrolopyrimidine as selective multidrug-resistance-associated protein inhibitors in multidrug resistance.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 5.91 | 6.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29743 | — | — | 1 | 6.63 |
| CHEMBL29631 | — | — | 1 | 6.53 |
| CHEMBL28168 | — | — | 1 | 6.45 |
| CHEMBL285343 | — | — | 1 | 6.35 |
| CHEMBL439727 | — | — | 1 | 6.22 |
| CHEMBL27536 | — | — | 1 | 6.19 |
| CHEMBL27257 | — | — | 1 | 6.14 |
| CHEMBL281326 | — | — | 1 | 6.11 |
| CHEMBL282156 | — | — | 1 | 6.11 |
| CHEMBL283255 | — | — | 1 | 6.07 |
| CHEMBL283253 | — | — | 1 | 6.02 |
| CHEMBL26039 | — | — | 1 | 5.99 |
| CHEMBL26081 | — | — | 1 | 5.96 |
| CHEMBL26678 | — | — | 1 | 5.92 |
| CHEMBL27007 | — | — | 1 | 5.92 |
| CHEMBL27415 | — | — | 1 | 5.91 |
| CHEMBL26150 | — | — | 1 | 5.87 |
| CHEMBL284024 | — | — | 1 | 5.83 |
| CHEMBL284676 | — | — | 1 | 5.77 |
| CHEMBL25867 | — | — | 1 | 5.76 |
| CHEMBL281496 | — | — | 1 | 5.72 |
| CHEMBL25731 | — | — | 1 | 5.72 |
| CHEMBL25905 | — | — | 1 | 5.70 |
| CHEMBL28629 | — | — | 1 | 5.68 |
| CHEMBL418382 | — | — | 1 | 5.61 |
| CHEMBL283438 | — | — | 1 | 5.48 |
| CHEMBL430724 | — | — | 1 | 5.33 |
| CHEMBL26779 | — | — | 1 | 5.22 |
| CHEMBL282365 | — | — | 1 | 5.12 |
| CHEMBL25903 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29743 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL29631 | — | IC50 | = | 294.0 | nM | 6.53 |
| CHEMBL28168 | — | IC50 | = | 356.0 | nM | 6.45 |
| CHEMBL285343 | — | IC50 | = | 443.0 | nM | 6.35 |
| CHEMBL439727 | — | IC50 | = | 608.0 | nM | 6.22 |
| CHEMBL27536 | — | IC50 | = | 651.0 | nM | 6.19 |
| CHEMBL27257 | — | IC50 | = | 731.0 | nM | 6.14 |
| CHEMBL281326 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL282156 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL283255 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL283253 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL26039 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL26081 | — | IC50 | = | 1110.0 | nM | 5.96 |
| CHEMBL26678 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL27007 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL27415 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL26150 | — | IC50 | = | 1340.0 | nM | 5.87 |
| CHEMBL284024 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL284676 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL25867 | — | IC50 | = | 1738.0 | nM | 5.76 |
| CHEMBL25731 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL281496 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL25905 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL28629 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL418382 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL283438 | — | IC50 | = | 3320.0 | nM | 5.48 |
| CHEMBL430724 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL26779 | — | IC50 | = | 6040.0 | nM | 5.22 |
| CHEMBL282365 | — | IC50 | = | 7560.0 | nM | 5.12 |
| CHEMBL26686 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL287400 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL27191 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL431503 | — | IC50 | - | nM | - | |
| CHEMBL286948 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL430925 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL28584 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL283693 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL30052 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL25903 | — | IC50 | > | 10000.0 | nM | - |