Assay Detail
Binding
CHEMBL751621
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Compound was evaluated for its ability to displace [3H]CCP binding for NMDA receptor
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Excitatory amino acids: 6-phosphonomethyltetrahydro-4-pyrimidinecarboxylic acids and their acyclic analogues are competitive N-methyl-D-aspartic acid receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.47 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39664 | SELFOTEL | 2.0 | 1 | 7.62 |
| CHEMBL22304 | — | — | 1 | 7.55 |
| CHEMBL302889 | — | — | 1 | 6.89 |
| CHEMBL304704 | — | — | 1 | 6.62 |
| CHEMBL68347 | — | — | 1 | 6.38 |
| CHEMBL293473 | — | — | 1 | 5.84 |
| CHEMBL67775 | — | — | 1 | 5.64 |
| CHEMBL67244 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39664 | SELFOTEL | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL22304 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL302889 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL304704 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL68347 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL293473 | — | IC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL67775 | — | IC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL67244 | — | IC50 | = | 5950.0 | nM | 5.22 |