Assay Detail
Binding
CHEMBL751630
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Compound was tested in vitro for inhibition of binding of [3H]-CGS- 19755 radioligand to NMDA receptor in rat brain membranes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Heteroatom-substitution as a strategy for increasing the potency of competitive NMDA antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.28 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL173031 | — | — | 1 | 7.77 |
| CHEMBL341344 | — | — | 1 | 7.12 |
| CHEMBL126881 | — | — | 1 | 6.96 |
| CHEMBL338894 | — | — | 1 | 6.55 |
| CHEMBL126297 | — | — | 1 | 5.89 |
| CHEMBL126727 | — | — | 1 | 5.64 |
| CHEMBL126231 | — | — | 1 | 5.24 |
| CHEMBL339737 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL173031 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL341344 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL126881 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL338894 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL126297 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL126727 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL126231 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL339737 | — | IC50 | = | 8300.0 | nM | 5.08 |