Assay Detail
Functional
CHEMBL751631
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested in vitro for its ability to inhibit depolarizations induced by 40 uM NMDA in a cortical slice (NMDA antagonist)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Heteroatom-substitution as a strategy for increasing the potency of competitive NMDA antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.38 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL173031 | — | — | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL173031 | — | IC50 | = | 4200.0 | nM | 5.38 |