Assay Detail
Functional
CHEMBL751632
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Compound was tested in vitro for its ability to inhibit depolarizations induced by 40 uM NMDA in a cortical slice (NMDA antagonist)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Heteroatom-substitution as a strategy for increasing the potency of competitive NMDA antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.90 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL338894 | — | — | 1 | 5.33 |
| CHEMBL339737 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL338894 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL339737 | — | IC50 | = | 34500.0 | nM | 4.46 |