Assay Detail
Binding
CHEMBL751653
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Inhibitory activity against human neuronal nitric oxide synthase
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.60 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL354788 | — | — | 1 | 7.22 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 7.05 |
| CHEMBL7890 | L-NAME | 2.0 | 1 | 6.82 |
| CHEMBL447183 | — | — | 1 | 6.00 |
| CHEMBL352659 | — | — | 1 | 6.00 |
| CHEMBL7889 | L-NIL | — | 1 | 5.82 |
| CHEMBL174310 | — | — | 1 | 5.48 |
| CHEMBL354516 | — | — | 1 | 5.46 |
| CHEMBL225304 | PIMAGEDINE | 2.0 | 1 | 5.23 |
| CHEMBL367556 | — | — | 1 | 4.92 |
| CHEMBL174290 | — | — | 1 | 4.40 |
| CHEMBL170176 | — | — | 1 | 4.30 |
| CHEMBL170580 | — | — | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL354788 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL256147 | TILARGININE | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL7890 | L-NAME | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL447183 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL352659 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL7889 | L-NIL | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL174310 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL354516 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL225304 | PIMAGEDINE | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL367556 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL174290 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL170176 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL170580 | — | IC50 | = | 70000.0 | nM | 4.16 |