Assay Detail
Binding
CHEMBL751656
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In vitro inhibition of human neuronal nitric oxide synthase.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.66 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302657 | — | — | 1 | 8.00 |
| CHEMBL59925 | — | — | 1 | 7.01 |
| CHEMBL40833 | — | — | 1 | 6.96 |
| CHEMBL113438 | — | — | 1 | 6.62 |
| CHEMBL447183 | — | — | 1 | 6.13 |
| CHEMBL113793 | — | — | 1 | 6.00 |
| CHEMBL7889 | L-NIL | — | 1 | 5.80 |
| CHEMBL62077 | — | — | 1 | 5.66 |
| CHEMBL114500 | — | — | 1 | 5.18 |
| CHEMBL112866 | — | — | 1 | 5.11 |
| CHEMBL114551 | GW-274150 | 2.0 | 1 | 4.75 |
| CHEMBL420671 | — | — | 1 | 4.68 |
| CHEMBL112747 | — | — | 1 | 4.55 |
| CHEMBL112246 | — | — | 1 | 4.50 |
| CHEMBL112198 | — | — | 1 | 4.02 |
| CHEMBL112247 | — | — | 1 | - |
| CHEMBL112139 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302657 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL59925 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL40833 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL113438 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL447183 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL113793 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL7889 | L-NIL | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL62077 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL114500 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL112866 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL114551 | GW-274150 | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL420671 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL112747 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL112246 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL112198 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL112247 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL112139 | — | IC50 | > | 100000.0 | nM | - |