Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL751677

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against hepatitis C virus (HCV) NS3 protease (full-length)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hepacivirus hominis
Confidence 9 — Direct single protein target
Curated By Expert

Target

NS3 (CHEMBL1293269)
Type SINGLE PROTEIN
Organism Hepatitis C virus

Publication

Inhibition of hepatitis C virus NS3 protease activity by product-based peptides is dependent on helicase domain.
Johansson A, Hubatsch I, Akerblom E, Lindeberg G, Winiwarter S, Danielson UH, Hallberg A.
Bioorg Med Chem Lett (2001) 11 : 203 -206
PubMed 11206459 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 6.23 7.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2369589 1 7.92
CHEMBL417559 1 7.39
CHEMBL60967 1 6.75
CHEMBL61390 1 6.66
CHEMBL431559 1 6.48
CHEMBL62717 1 6.44
CHEMBL64867 1 6.36
CHEMBL305570 1 6.31
CHEMBL304005 1 6.00
CHEMBL64618 1 5.98
CHEMBL62433 1 5.96
CHEMBL294440 1 5.91
CHEMBL303541 1 5.81
CHEMBL293631 1 5.68
CHEMBL303340 1 5.39
CHEMBL60512 1 4.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2369589 Ki = 12.0 nM 7.92
CHEMBL417559 Ki = 41.0 nM 7.39
CHEMBL60967 Ki = 180.0 nM 6.75
CHEMBL61390 Ki = 220.0 nM 6.66
CHEMBL431559 Ki = 330.0 nM 6.48
CHEMBL62717 Ki = 360.0 nM 6.44
CHEMBL64867 Ki = 440.0 nM 6.36
CHEMBL305570 Ki = 490.0 nM 6.31
CHEMBL304005 Ki = 1000.0 nM 6.00
CHEMBL64618 Ki = 1040.0 nM 5.98
CHEMBL62433 Ki = 1100.0 nM 5.96
CHEMBL294440 Ki = 1240.0 nM 5.91
CHEMBL303541 Ki = 1540.0 nM 5.81
CHEMBL293631 Ki = 2100.0 nM 5.68
CHEMBL303340 Ki = 4100.0 nM 5.39
CHEMBL60512 Ki = 25000.0 nM 4.60