Assay Detail
Binding
CHEMBL751792
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested in vitro for the displacement of the radioligand (+)-[3H]-MK-801 from synaptic plasma membranes from rat cortex against N-methyl-D-aspartate glutamate receptor
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Plasma |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Chiral synthesis and pharmacological evaluation of NPS 1407: a potent, stereoselective NMDA receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.53 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL284237 | DIZOCILPINE | 2.0 | 1 | 8.25 |
| CHEMBL293092 | — | — | 1 | 6.85 |
| CHEMBL294852 | — | — | 1 | 6.64 |
| CHEMBL78767 | — | — | 1 | 6.12 |
| CHEMBL421144 | — | — | 1 | 5.98 |
| CHEMBL79133 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL284237 | DIZOCILPINE | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL293092 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL294852 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL78767 | — | IC50 | = | 762.0 | nM | 6.12 |
| CHEMBL421144 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL79133 | — | IC50 | = | 4500.0 | nM | 5.35 |