Assay Detail
Binding
CHEMBL751794
Review assay metadata, readout intent, target linkage, and publication context from the same page.
relative affinity against N-methyl-D-aspartate glutamate receptor in caudate using [3H](+)-MK-801 as radioligand
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Modified ibogaine fragments: synthesis and preliminary pharmacological characterization of 3-ethyl-5-phenyl-1,2,3,4,5, 6-hexahydroazepino[4,5-b]benzothiophenes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.51 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222287 | IBOGAINE | 2.0 | 1 | 5.28 |
| CHEMBL343956 | — | — | 1 | 4.50 |
| CHEMBL341805 | — | — | 1 | 4.50 |
| CHEMBL141863 | — | — | 1 | 4.38 |
| CHEMBL139081 | — | — | 1 | 4.33 |
| CHEMBL336437 | — | — | 1 | 4.09 |
| CHEMBL23529 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222287 | IBOGAINE | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL343956 | — | IC50 | = | 31400.0 | nM | 4.50 |
| CHEMBL341805 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL141863 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL139081 | — | IC50 | = | 46600.0 | nM | 4.33 |
| CHEMBL336437 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL23529 | — | IC50 | = | - | nM | - |