Assay Detail
Binding
CHEMBL751817
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Inhibition constant for HCV NS3 protease substrate binding site
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Non-peptidic small-molecule inhibitors of the single-chain hepatitis C virus NS3 protease/NS4A cofactor complex discovered by structure-based NMR screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.05 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL82941 | — | — | 1 | 6.10 |
| CHEMBL189314 | — | — | 1 | 6.00 |
| CHEMBL83092 | — | — | 1 | 4.10 |
| CHEMBL82121 | — | — | 1 | 4.00 |
| CHEMBL83907 | — | — | 1 | - |
| CHEMBL83906 | IODOALPHIONIC ACID | 2.0 | 1 | - |
| CHEMBL84385 | — | — | 1 | - |
| CHEMBL79728 | — | — | 1 | - |
| CHEMBL310394 | — | — | 1 | - |
| CHEMBL83650 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL82941 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL189314 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL83092 | — | Ki | = | 80000.0 | nM | 4.10 |
| CHEMBL82121 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL83907 | — | Ki | = | 210000.0 | nM | - |
| CHEMBL83906 | IODOALPHIONIC ACID | Ki | = | 140000.0 | nM | - |
| CHEMBL84385 | — | Ki | = | 310000.0 | nM | - |
| CHEMBL79728 | — | Ki | = | 180000.0 | nM | - |
| CHEMBL310394 | — | Ki | = | 260000.0 | nM | - |
| CHEMBL83650 | — | Ki | = | 600000.0 | nM | - |