Assay Detail
Binding
CHEMBL751882
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity against rat cortical and hippocampal membrane strychnine-insensitive N-methyl-D-aspartate glutamate receptor 1 using [3H]-gly
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
3-(2-carboxyindol-3-yl)propionic acid derivatives: antagonists of the strychnine-insensitive glycine receptor associated with the N-methyl-D-aspartate receptor complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.46 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50267 | — | — | 1 | 7.10 |
| CHEMBL31344 | — | — | 1 | 6.85 |
| CHEMBL311389 | 7-CHLOROKYNURENIC ACID | -1.0 | 1 | 6.40 |
| CHEMBL295718 | — | — | 1 | 5.57 |
| CHEMBL50160 | — | — | 1 | 5.22 |
| CHEMBL301556 | — | — | 1 | 5.22 |
| CHEMBL417544 | — | — | 1 | 4.85 |
| CHEMBL299155 | TRANSTORINE | 1.0 | 1 | 4.80 |
| CHEMBL278097 | — | — | 1 | 4.52 |
| CHEMBL53744 | — | — | 1 | 4.05 |
| CHEMBL278390 | INDOLE-2-CARBOXYLIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50267 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL31344 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL311389 | 7-CHLOROKYNURENIC ACID | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL295718 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL50160 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL301556 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL417544 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL299155 | TRANSTORINE | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL278097 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL53744 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL278390 | INDOLE-2-CARBOXYLIC ACID | IC50 | = | 106000.0 | nM | - |