Assay Detail
Binding
CHEMBL751927
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Nitric Oxide Synthase Inhibitory activity tested against bovine brain nNOS (Neuronal nitric oxide synthase)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.13 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1204421 | — | — | 1 | 6.89 |
| CHEMBL1202118 | — | — | 1 | 6.50 |
| CHEMBL1202106 | — | — | 1 | 6.48 |
| CHEMBL1204423 | — | — | 1 | 6.35 |
| CHEMBL1202117 | — | — | 1 | 6.11 |
| CHEMBL2092928 | — | — | 1 | 6.05 |
| CHEMBL1204426 | — | — | 1 | 5.96 |
| CHEMBL2113674 | — | — | 1 | 5.90 |
| CHEMBL1202116 | — | — | 1 | 5.77 |
| CHEMBL1204422 | — | — | 1 | 5.70 |
| CHEMBL2092929 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1204421 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL1202118 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL1202106 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL1204423 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL1202117 | — | Ki | = | 770.0 | nM | 6.11 |
| CHEMBL2092928 | — | Ki | = | 890.0 | nM | 6.05 |
| CHEMBL1204426 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL2113674 | — | Ki | = | 1250.0 | nM | 5.90 |
| CHEMBL1202116 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL1204422 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL2092929 | — | Ki | = | 2000.0 | nM | 5.70 |