Assay Detail
Binding
CHEMBL751989
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Binding affinity against opioid receptor kappa 1 using [3H]- U-69,593 radioligand
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
From hit to lead. Combining two complementary methods for focused library design. Application to mu opiate ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 6.54 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2368861 | BUPRENORPHINE HYDROCHLORIDE | 4.0 | 1 | 8.92 |
| CHEMBL80 | NALOXONE | 4.0 | 1 | 8.82 |
| CHEMBL114379 | — | — | 1 | 8.77 |
| CHEMBL115222 | — | — | 1 | 8.68 |
| CHEMBL420863 | — | — | 1 | 8.54 |
| CHEMBL115652 | — | — | 1 | 8.24 |
| CHEMBL325842 | — | — | 1 | 7.50 |
| CHEMBL324297 | — | — | 1 | 7.43 |
| CHEMBL326962 | — | — | 1 | 7.25 |
| CHEMBL895 | NALBUPHINE | 4.0 | 1 | 7.08 |
| CHEMBL115280 | — | — | 1 | 7.00 |
| CHEMBL325750 | — | — | 1 | 6.98 |
| CHEMBL1707 | LOPERAMIDE HYDROCHLORIDE | 4.0 | 1 | 6.81 |
| CHEMBL2096625 | — | — | 1 | 6.66 |
| CHEMBL112191 | — | — | 1 | 6.57 |
| CHEMBL115444 | — | — | 1 | 6.55 |
| CHEMBL115229 | — | — | 1 | 6.51 |
| CHEMBL114825 | — | — | 1 | 6.48 |
| CHEMBL651 | METHADONE | 4.0 | 1 | 6.29 |
| CHEMBL114280 | — | — | 1 | 6.29 |
| CHEMBL325674 | — | — | 1 | 6.21 |
| CHEMBL326320 | — | — | 1 | 6.10 |
| CHEMBL114824 | — | — | 1 | 6.00 |
| CHEMBL115284 | — | — | 1 | 5.97 |
| CHEMBL114204 | — | — | 1 | 5.88 |
| CHEMBL324257 | — | — | 1 | 5.83 |
| CHEMBL596 | FENTANYL | 4.0 | 1 | 5.80 |
| CHEMBL333843 | — | — | 1 | 5.76 |
| CHEMBL326538 | — | — | 1 | 5.74 |
| CHEMBL115076 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2368861 | BUPRENORPHINE HYDROCHLORIDE | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL80 | NALOXONE | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL114379 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL115222 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL420863 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL115652 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL325842 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL324297 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL326962 | — | IC50 | = | 56.1 | nM | 7.25 |
| CHEMBL895 | NALBUPHINE | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL115280 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL325750 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL1707 | LOPERAMIDE HYDROCHLORIDE | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL2096625 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL112191 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL115444 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL115229 | — | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL114825 | — | IC50 | = | 333.0 | nM | 6.48 |
| CHEMBL651 | METHADONE | IC50 | = | 512.0 | nM | 6.29 |
| CHEMBL114280 | — | IC50 | = | 507.0 | nM | 6.29 |
| CHEMBL325674 | — | IC50 | = | 617.0 | nM | 6.21 |
| CHEMBL326320 | — | IC50 | = | 797.0 | nM | 6.10 |
| CHEMBL114824 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL115284 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL114204 | — | IC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL324257 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL596 | FENTANYL | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL333843 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL326538 | — | IC50 | = | 1810.0 | nM | 5.74 |
| CHEMBL115076 | — | IC50 | = | 2145.0 | nM | 5.67 |
| CHEMBL420500 | — | IC50 | = | 2235.0 | nM | 5.65 |
| CHEMBL113811 | — | IC50 | = | 2280.0 | nM | 5.64 |
| CHEMBL607 | MEPERIDINE | IC50 | = | 2370.0 | nM | 5.62 |
| CHEMBL325874 | — | IC50 | = | 3550.0 | nM | 5.45 |
| CHEMBL332697 | — | IC50 | = | 4030.0 | nM | 5.39 |
| CHEMBL324170 | — | IC50 | = | 5070.0 | nM | 5.29 |
| CHEMBL111918 | — | IC50 | = | 6570.0 | nM | 5.18 |
| CHEMBL114940 | — | IC50 | = | 6540.0 | nM | 5.18 |
| CHEMBL324479 | — | IC50 | = | 7240.0 | nM | 5.14 |
| CHEMBL419214 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL114327 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL115549 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL324142 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL324471 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL325697 | — | IC50 | > | 10000.0 | nM | - |