Assay Detail
Functional
CHEMBL752033
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against Opioid receptor mu 1 iin a guinea pig ileum assay
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 5.97 | 6.30 |
| pA2 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106853 | — | — | 1 | 6.30 |
| CHEMBL104436 | — | — | 1 | 5.80 |
| CHEMBL2370386 | — | — | 1 | 5.80 |
| CHEMBL107386 | — | — | 1 | - |
| CHEMBL567175 | NALTRINDOLE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106853 | — | Kd | = | 501.19 | nM | 6.30 |
| CHEMBL104436 | — | Kd | = | 1584.89 | nM | 5.80 |
| CHEMBL2370386 | — | Kd | = | 1584.89 | nM | 5.80 |
| CHEMBL107386 | — | Kd | = | 100000000.0 | nM | - |
| CHEMBL567175 | NALTRINDOLE | pA2 | = | 7.3 | nM | - |