Assay Detail
Binding
CHEMBL752158
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]nisoxetine binding to norepinephrine transporter (NET) of rat cortical homogenates
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Substituted diphenyl sulfides as selective serotonin transporter ligands: synthesis and in vitro evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.97 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278165 | — | — | 1 | 8.24 |
| CHEMBL429065 | — | — | 1 | 7.89 |
| CHEMBL22743 | — | — | 1 | 7.55 |
| CHEMBL277045 | — | — | 1 | 7.10 |
| CHEMBL22216 | — | — | 1 | 6.97 |
| CHEMBL23033 | — | — | 1 | 6.97 |
| CHEMBL284002 | — | — | 1 | 6.67 |
| CHEMBL22183 | — | — | 1 | 6.49 |
| CHEMBL22259 | — | — | 1 | 6.49 |
| CHEMBL23034 | — | — | 1 | 6.17 |
| CHEMBL278809 | — | — | 1 | 6.15 |
| CHEMBL22436 | — | — | 1 | - |
| CHEMBL441022 | — | — | 1 | - |
| CHEMBL22643 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278165 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL429065 | — | Ki | = | 12.8 | nM | 7.89 |
| CHEMBL22743 | — | Ki | = | 28.4 | nM | 7.55 |
| CHEMBL277045 | — | Ki | = | 80.2 | nM | 7.10 |
| CHEMBL22216 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL23033 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL284002 | — | Ki | = | 212.0 | nM | 6.67 |
| CHEMBL22183 | — | Ki | = | 325.0 | nM | 6.49 |
| CHEMBL22259 | — | Ki | = | 326.0 | nM | 6.49 |
| CHEMBL23034 | — | Ki | = | 683.0 | nM | 6.17 |
| CHEMBL278809 | — | Ki | = | 714.0 | nM | 6.15 |
| CHEMBL22436 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL441022 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL22643 | — | Ki | > | 1000.0 | nM | - |