Assay Detail
Binding
CHEMBL752169
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Binding affinity against muscarinic cholinergic receptor from rat brain, using [3H]-QNB as radioligand.
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis and receptor binding properties of fluoro- and iodo-substituted high affinity sigma receptor ligands: identification of potential PET and SPECT sigma receptor imaging agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 4.63 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71049 | — | — | 1 | 5.16 |
| CHEMBL70861 | — | — | 1 | 4.49 |
| CHEMBL324392 | — | — | 1 | 4.25 |
| CHEMBL70540 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71049 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL70861 | — | Ki | = | 32030.0 | nM | 4.49 |
| CHEMBL324392 | — | Ki | = | 56850.0 | nM | 4.25 |
| CHEMBL70540 | — | Ki | = | 682500.0 | nM | - |