Assay Detail
Binding
CHEMBL752187
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]naloxone from Opioid receptor mu 1 in guinea pig brain membrane
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Opioid agonist and antagonist bivalent ligands. The relationship between spacer length and selectivity at multiple opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.92 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL610018 | — | — | 1 | 8.85 |
| CHEMBL3350130 | — | — | 1 | 8.82 |
| CHEMBL3350137 | — | — | 1 | 8.80 |
| CHEMBL3350129 | — | — | 1 | 8.77 |
| CHEMBL3350138 | — | — | 1 | 8.64 |
| CHEMBL3350136 | — | — | 1 | 8.00 |
| CHEMBL3350132 | — | — | 1 | 7.85 |
| CHEMBL3350135 | — | — | 1 | 7.75 |
| CHEMBL3350140 | — | — | 1 | 7.66 |
| CHEMBL3350134 | — | — | 1 | 7.64 |
| CHEMBL3350128 | — | — | 1 | 7.47 |
| CHEMBL3350133 | — | — | 1 | 7.36 |
| CHEMBL3350127 | — | — | 1 | 7.30 |
| CHEMBL3350139 | — | — | 1 | 7.20 |
| CHEMBL607319 | — | — | 1 | 6.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL610018 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL3350130 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL3350137 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL3350129 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL3350138 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL3350136 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL3350132 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL3350135 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL3350140 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL3350134 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL3350128 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL3350133 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL3350127 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL3350139 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL607319 | — | Ki | = | 180.0 | nM | 6.75 |