Assay Detail
Binding
CHEMBL752244
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In vitro inhibition of NMDA responses at NR1A/2B receptor expressed in Xenopus oocytes
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Oocyte |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, NMDA 3A (CHEMBL342) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Subtype-selective N-methyl-D-aspartate receptor antagonists: benzimidazalone and hydantoin as phenol replacements.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.74 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54778 | — | — | 1 | 7.60 |
| CHEMBL56643 | — | — | 1 | 7.02 |
| CHEMBL293491 | — | — | 1 | 6.96 |
| CHEMBL56702 | — | — | 1 | 5.47 |
| CHEMBL58826 | — | — | 1 | 5.00 |
| CHEMBL58992 | — | — | 1 | 4.96 |
| CHEMBL56155 | — | — | 1 | 4.57 |
| CHEMBL442165 | — | — | 1 | 4.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54778 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL56643 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL293491 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL56702 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL58826 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL58992 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL56155 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL442165 | — | IC50 | = | 49000.0 | nM | 4.31 |