Compound Detail
CHEMBL56155
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Basic Information
| ChEMBL ID | CHEMBL56155 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LWKRPIQDBOYLDR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
315.4
MW (Da)
1.88
ALogP
3
HBA
1
HBD
52.6
PSA (Ų)
0.82
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 3A CHEMBL342 | IC50 | 4.57 | 4.57 | 27000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 3A | IC50 | = | 27000.0 | nM | 4.57 | In vitro inhibition of NMDA responses at NR1A/2B receptor expressed in Xenopus o... | 10794706 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10794706 | 10.1021/jm990537r | Glutamate receptor ionotropic, NMDA 3A | 2 |
| 20692832 | 10.1016/j.bmcl.2010.07.043 | Glutamate NMDA receptor; GRIN1/GRIN2B | 2 |
| 10794706 | 10.1021/jm990537r | Glutamate receptor ionotropic, NMDA 2C | 1 |
Data from ChEMBL 36 via Core Engine